两种类型的植入组织工程支架的胫骨缺损的计算模型几何形状，β-磷酸三钙（β-TCP）和聚己内（PCL）/εβ-TCP，由体内缺陷真实的µ-CT图像构建而成。研究人员对模仿体内的轴向压缩载荷和四点弯曲下的每个缺陷进行了模拟。利用压力分布分析法分析了各缺陷的力学稳定性。

这一分析的结果强调了愈伤组织体积和两个支架体积、刚度对这些缺陷的承载能力的影响。临床上使用基于图像的方法来预测外固定支架的安全性为每个缺陷进行评价。计算分析这些措施的结果比较表明必须注意这些措施的解释。

原文摘要如下：

Computational modelling of ovine critical-sized tibial defects with implanted scaffolds and prediction of the safety of fixator removal

Doyle H¹, Lohfeld S², Dürselen L³, McHugh P²

Abstract: Computational model geometries of tibial defects with two types of implanted tissue engineering scaffolds, β-tricalcium phosphate (β-TCP) and poly-ε-caprolactone (PCL)/β-TCP, are constructed from µ-CT scan images of the real in vivo defects. Simulations of each defect under four-point bending and under simulated in vivo axial compressive loading are performed. The mechanical stability of each defect is analysed using stress distribution analysis. The results of this analysis highlights the influence of callus volume, and both scaffold volume and stiffness, on the load-bearing abilities of these defects. Clinically-used image-based methods to predict the safety of removing external fixation are evaluated for each defect. Comparison of these measures with the results of computational analyses indicates that care must be taken in the interpretation of these measures.

Keywords: Critical sized defect, Defect stability, External fixator, Orthopaedic scaffold, PCL, β-tricalcium phosphate

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