绵羊传染性蹄炎（CODD）是绵羊发生严重跛行的原因并且三个梅毒螺旋体的遗传谱系梅毒螺旋体介质/文氏密螺旋体类似物，蚀疮溃疡密螺旋体类似物和梅毒螺旋体蹄已证实与临床疾病有关。

该研究的目的是：（1）描述与先前建立的每个临床病变分级相关的组织病理学变化，和（2）研究梅毒螺旋体等微生物与所观察到的组织病理变化的免疫组化的相关性。早期病变特点是末端蹄部皮肤淋巴浆细胞浸润，以及出现化脓性角膜炎和角膜内脓疱。疾病发展到更高阶段，蹄背侧壁与坏死性的、纤维蛋白化脓性的渗出液及皮炎完全分离。晚期病变大多得到分解，但在角质层和末节指骨背侧骨膜反应中仍存在较轻的化脓性改变。大量的梅毒螺旋体等微生物被确定处于早期病变（此外，还有晚期的，更高级的病变），与所观察到的组织病理变化有关。这项研究的结果为三个CODD相关的梅毒螺旋体的遗传谱系都涉及该病的发病机制的假设提供了一些证据支持。

原文摘要如下：

Histopathological Characterization of the Lesions of Contagious Ovine Digital Dermatitis and Immunolabelling of Treponema-like Organisms

Angell JW¹, Crosby-Durrani HE², Duncan JS³, Carter SD⁴, Blundell R²

Abstract: Contagious ovine digital dermatitis (CODD) is a cause of severe lameness in sheep and the three Treponema phylogroups Treponema medium/Treponema vincentii-like, Treponema phagedenis-like and Treponema pedis have been associated with clinical disease. The aims of this study were: (1) to describe the histopathological changes associated with each previously established grade of clinical lesion, and (2) to investigate immunohistochemically the association of the Treponema-like organisms with the observed histopathological changes. Early lesions were characterized by lymphoplasmacytic infiltration of the distal digital skin, with suppurative coronitis and intracorneal pustules. In more advanced stages of the disease there was complete separation of the dorsal wall of the hoof with a necrotizing and fibrinosuppurative exudate and dermatitis. The later lesions were mostly resolved, but with milder suppurative changes remaining within the cornified layer and periosteal reaction of the dorsal aspect of the distal phalanx. Large numbers of Treponema-like organisms were identified within early grade lesions (as well as later, more advanced grade lesions) and were specifically associated with the observed histopathological changes. The results of this study provide some evidence in support of the hypothesis that the three CODD-associated Treponema phylogroups are involved in the aetiopathogenesis of this disease.

Keywords: Treponema, contagious ovine digital dermatitis, histopathology, sheep

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