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有研究报道了在南美洲，欧洲和亚洲地区牛HoBi类瘟病毒的自然感染。在中国，虽然报道了HoBi类瘟病毒的检测，但是流行病学的调查是有限的。从2014年1月至2015年10月，在中国中部的河南省的几个绵羊/山羊群体经过抗生素治疗后呼吸系统疾病逐渐康复。为了确定它是否是HoBi类瘟病毒引起的这种症状，通过血清学和PCR收集分析49份血清样本和22个鼻拭子。
血清学结果显示在中国中部小反刍动物的患病率为12.2%（6/49）。瘟病毒阳性样本的部分5’UTR核苷酸序列分析表明HoBi类瘟病毒可能在中国绵羊和山羊群体中流行了一段时间，并已经演变成新的基因簇。很明显，该研究提供了中国山羊/绵羊HoBi类瘟病毒自然感染的分子证据。
原文摘要如下：
Identification of Natural Infections in Sheep/Goats with HoBi-like Pestiviruses in China
Shi H1, Kan Y1, Yao L1, Leng C1, Tang Q1, Ji J1, Sun S2
Abstract: The natural infections of HoBi-like pestiviruses in cattle have been reported in South America, Europe and Asia. In China, although the detections of HoBi-like pestivirus have been reported, the epidemiological investigation was limited. From January 2014 to October 2015, several flocks of sheep/goats in Henan province in central China suffered respiratory diseases which were recovered slowly after antibiotics treatment. To test whether it is the HoBi-like pestivirus caused this symptom, 49 serum samples and 22 nasal swabs were then collected for analysis by serology and RT-PCR. Serological result revealed that prevalence of pestivirus in small ruminants was 12.2% (6/49) in central China. Sequence analysis of partial 5'-UTR nucleotides of pestivirus-positive samples suggested that HoBi-like pestivirus might have circulated in sheep/goats of China for a period and have evolved into new genotype clusters. It is apparent that the study provides the molecular evidence of natural infections in goat/sheep species with HoBi-like pestiviruses in China.
Keywords: Bovine viral diarrhoea virus, China, HoBi-like pestiviruses, goat, sheep
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